ETHYL(3-HYDROXY-n-BUTYL)BARBITURIC ACID AS A METABOLITE OF NEONAL
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Ethyl(3-hydroxy-n-butyl)barbituric acid as a metabolite of neonal.
Earlier studies (1, 2) from this laboratory indicated that in the dog the alkyl side chains of pentobarbital and Amytal do not undergo w oxidation but are subject to oxidation at the y-carbon atom of the amyl chains. Dogs excrete pentobarbital as two optically active diastereoisomers of ethyl(3hydroxy-1-methylbutyl)barbituric acid and Amytal as ethyl(3-hydroxyisoamyl)barbituric acid. In order t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)50913-9